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Recovery vs. Recurrence: Optimizing Maintenance Therapy for Patients with Bipolar Disorder

Premiere Date: Wednesday, May 3, 2006

This activity offers CE credit for:

1. Physicians (ACCME/AMA PRA Category 1)
2. Pharmacists (ACPE)
3. Psychologists (APA)
4. Social Workers (NASW)
5. Certified Case Managers (CCMC)

All other clinicians will receive a Certificate of Attendance stating this activity was certified for AMA PRA Category 1 Credit™

Credit Expiration Date:
Thursday, May 3, 2007
Note: Credit Is No Longer Available

Faculty

Prakash S. Masand, MD  Consulting Professor of Psychiatry Duke University Medical Center Durham, NC

Paul E. Keck, Jr., MD  President-CEO, Lindner Center of HOPE Professor of Psychiatry & Behavior Neuroscience University of Cincinnati College of Medicine Cincinnati, OH

Roger S. McIntyre, MD, FRCPC  University of Toronto University Health Network Toronto, ON Chairman and Executive Director, Brain and Cognition, Depression and Bipolar Support Alliance (DBSA) Chicago, IL Clinical Professor, Department of Psychiatry and Neurosciences University of California School of Medicine Riverside, CA

Statement of Need

Bipolar disorder causes significant morbidity and mortality (including suicide), is one of the leading causes of disability worldwide, and has a deleterious impact on social and occupational functioning.(1) Current practice guidelines recommend that long-term treatment be considered following a single severe manic episode to try to ameliorate the future course of the illness by preventing relapse.(2) The Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) reports that even with best-practice guidelines (medication combined with psychosocial interventions), only 858 of 1,469 patients (58.4%) with bipolar disorder achieved recovery; of those, 416 (48.5%) experienced a recurrence within 2 years.(3) In addition, clinicians need to consider side effect profiles when choosing medications for long-term treatment. In particular, patients with bipolar disorder are more prone to morbidity and mortality from obesity, diabetes, and cardiovascular causes.(4) In this evidence-based CME Outfitters/psychCME TV activity, the experts will discuss the evaluation and application of individualized treatment strategies for optimizing long-term maintenance therapy for patients with bipolar disorder.

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1. Gitlin MJ, Swendsen J, Heller TL, Hammen C. Relapse and impairment in bipolar disorder. Am J Psychiatry 1995;152:1635-1640.
2. APA, Practice guidelines for the treatment of patients with bipolar disorder (revision). Am J Psychiatry 2002;159(suppl 4):1-50.
3. Perlis RH, Ostacher MJ, Patel JK, et al. Predictors of recurrence in bipolar disorder: Primary outcomes from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD). Am J Psychiatry 2006;163:217-224.
4. Morriss R, Mohammed FA. Metabolism, lifestyle and bipolar affective disorder. J Psychopharmacol 2005;19(6 Suppl):94-101.

Activity Goal

To provide evidence-based educational information and clinical context regarding the efficacy of medications used in maintenance treatment of bipolar disorder.

Learning Objectives

At the end of this CE activity, participants should be able to:

• Evaluate the evidence base for monotherapy and adjunctive therapies used in the maintenance phase of bipolar disorder.
• Identify and differentiate individualized treatment strategies for patients with bipolar disorder based on side effect profile.
• Compare and contrast pharmacotherapies based on current practice guidelines, recent evidence, and indications for maintenance therapy in bipolar disorder.

Target Audience

Physicians, physician assistants, nurse practitioners, nurses, psychologists, social workers, certified case managers, pharmacists, and other healthcare professionals with an interest in mental health.

Credit Information

CME Credit (Physicians):
CME Outfitters, LLC, is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. CME Outfitters, LLC, designates this educational activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

CNE Credit (Nurses):
This Educational Activity is presented by CME Outfitters, LLC, which has been approved as a provider of continuing education by the New York State Nurses Association, an accredited approver by the American Nurses Credentialing Center’s Commission on Accreditation. It has been assigned code 5UYSJZ-PRV-0495. 1.0 contact hour (Pharmacology)

CEP Credit (Psychologists):
CME Outfitters, LLC, is approved by the American Psychological Association to offer continuing education for psychologists. CME Outfitters, LLC, maintains responsibility for the program. 1.0 CE credits

NASW Credit (Social Workers):
This program was approved by the National Association of Social Workers (provider #886407722) for 1 continuing education contact hour.

CCMC Credit (Certified Case Managers):
This program has been approved for 1 hour by the Commission for Case Manager Certification (CCMC).

CPE Credit (Pharmacists):
CME Outfitters, LLC, is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education. 1.0 contact hours (0.1 CEUs)
Universal Program Number: 376-999-06-011-L01 (live presentation) 376-999-06-011-H01 (recorded programs)

To receive credit, participants must review all activity materials in their entirety, score 70% or above on a post-test, and fully complete and return both the credit request form and activity evaluation. A certificate or statement of credit will be mailed within 4-6 weeks to all who successfully complete these requirements.

Disclosure Declaration

All faculty participating in CME Outfitters continuing education activities are required to disclose any conflict(s) of interest related to the content of their presentation(s) as defined by the ACCME's Standards for Commercial Support, and other accrediting and regulatory bodies. Full disclosure of faculty relationships will be made on this website and within the activity course materials prior to the premiere date of this activity.

Questions about this activity? Call us at 877.CME.PROS (877.263.7767).