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Depression with Atypical Features Part II: Evidence for New Treatment Options in a Clinical Case Series

Premiere Date: Wednesday, November 1, 2006
Live Audioconference Series (15 sessions): November - December, 2006

This activity offers CE credit for:

1. Physicians (ACCME/AMA PRA Category 1)
2. Nurses (CNE)
3. Pharmacists (ACPE)
4. Psychologists (APA)
5. Social Workers (NASW)
6. Certified Case Managers (CCMC)

All other clinicians will receive a Certificate of Attendance stating this activity was certified for AMA PRA Category 1 Credit™

Credit Expiration Date:
Wednesday, December 12, 2007
Note: Credit Is No Longer Available

Faculty

Charles B. Nemeroff, MD, PhD  Professor and Chair Department of Psychiatry Mulva Clinic for the Neurosciences Director, Institute of Early Life Adversity Research Dell Medical School The University of Texas at Austin Austin, TX

Michael E. Thase, MD  Professor of Psychiatry Department of Psychiatry Perelman School of Medicine at the University of Pennsylvania Corporal Michael J. Crescenz Veterans Affairs Medical Center Philadelphia, PA

Statement of Need

Major depressive disorder affects an estimated 23 million adult Americans each year and is associated with significant morbidity and mortality, impaired social and physical functioning, and increased risk for suicide.(1,2) Over the years, a wide range of treatments have become available for depression, including monoamine oxidase inhibitors, tricyclic antidepressants, selective serotonin reuptake inhibitors, bupropion, venlafaxine, and cognitive behavioral therapy. Although a substantial proportion of patients do not initially respond to treatment, recent evidence from the STAR*D trials indicates that augmentation or switching to a different antidepressant can improve remission rates.(3,4) However, many antidepressants have contraindications or require dietary restrictions that could interfere with medication compliance. Emerging data demonstrate that newer delivery systems may provide improved antidepressant benefit, particularly in patients reporting depression with atypical features.(5) In this second of a two-part interactive and case-based CME Outfitters educational activity, the experts will use case studies to illustrate challenges facing clinicians in the treatment of depression and will explore novel treatment strategies in the management of depression.

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1. Depression and Bipolar Support Alliance, April, 2005.
2. Kessler RC, et al. The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R). JAMA 2003;289:3095-3105.
3. Trivedi MH, et al. Medication augmentation after the failure of SSRIs for depression. N Engl J Med 2006;354:1243-1252.
4. Rush AJ, et al. Bupropion-SR, sertraline, or venlafaxine-XR after failure of SSRIs for depression. N Engl J Med 2006;354:1231-1242.
5. Amsterdam J. A double-blind, placebo-controlled trial of the safety and efficacy of selegiline transdermal system without dietary restrictions in patients with major depressive disorder. J Clin Psychiatry 2003;64:208-214.

Activity Goal

To provide case-based educational information and clinical context regarding the appropriate treatment options for patients with depression with atypical features.

Learning Objectives

At the end of this CE activity, participants should be able to:

• Compare and contrast existing and novel treatment options for the treatment of depression with atypical features.
• Identify potential drug-drug interactions and the impact on treatment selection for depression with atypical features.
• Develop treatment strategies that utilize novel pharmacological approaches to achieve optimal outcomes in patients diagnosed with depression with atypical features.

Target Audience

Physicians, physician assistants, nurse practitioners, nurses, psychologists, social workers, certified case managers, pharmacists, and other healthcare professionals with an interest in mental health.

Credit Information

CME Credit (Physicians):
CME Outfitters, LLC, is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. CME Outfitters, LLC, designates this educational activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

CNE Credit (Nurses):
This Educational Activity is presented by CME Outfitters, LLC, which has been approved as a provider of continuing education by the New York State Nurses Association, an accredited approver by the American Nurses Credentialing Center’s Commission on Accreditation.

It has been assigned code 5UYSJZ-PRV-04103. 1.0 contact hour (Pharmacology)

CEP Credit (Psychologists):
CME Outfitters is approved by the American Psychological Association to sponsor continuing education for psychologists. CME Outfitters maintains responsibility for this program and its content. (1.0 CE credits)

NASW Credit (Social Workers):
This program was approved by the National Association of Social Workers (provider #886407722) for 1 continuing education contact hour.

CCMC Credit (Certified Case Managers):
This program has been approved for 1 hour by the Commission for Case Manager Certification (CCMC).

CPE Credit (Pharmacists):
CME Outfitters, LLC, is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education. 1.0 contact hours (0.1 CEUs)
Universal Program Number: 376-999-06-019-L01 (live interactive session) 376-999-06-019-H01 (recorded activities)

To receive credit, participants must review all activity materials in their entirety, score 70% or above on a post-test, and fully complete and return both the credit request form and activity evaluation. A certificate or statement of credit will be mailed within 4-6 weeks to all who successfully complete these requirements.

Disclosure Declaration

All faculty participating in CME Outfitters continuing education activities are required to disclose any conflict(s) of interest related to the content of their presentation(s) as defined by the ACCME's Standards for Commercial Support, and other accrediting and regulatory bodies. Full disclosure of faculty relationships will be made on this website and within the activity course materials prior to the premiere date of this activity.

Questions about this activity? Call us at 877.CME.PROS (877.263.7767).