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Unmasking the Fallout of Antipsychotic-Induced Weight Gain

neuroscienceCME TV

Premiere Date: Wednesday, August 1, 2007

This activity offers CE credit for:

  1. Physicians (ACCME/AMA PRA Category 1)
  2. Nurses (CNE)
  3. Pharmacists (ACPE)
  4. Psychologists (APA)
  5. Social Workers (NASW)
  6. Certified Case Managers (CCMC)


All other clinicians will receive a Certificate of Attendance stating this activity was certified for AMA PRA Category 1 Credit™

Credit Expiration Date:
Friday, August 1, 2008
Note: Credit Is No Longer Available

Faculty


Charles B. Nemeroff, MD, PhDCharles B. Nemeroff, MD, PhD 
Professor and Chair
Department of Psychiatry
Mulva Clinic for the Neurosciences
Director, Institute of Early Life Adversity Research
Dell Medical School
The University of Texas at Austin
Austin, TX

Philip D. Harvey, PhDPhilip D. Harvey, PhD 
Professor of Psychiatry and Behavioral Sciences
University of Miami Miller School of Medicine
Miami, FL

Roger S. McIntyre, MD, FRCPCRoger S. McIntyre, MD, FRCPC 
University of Toronto
University Health Network
Toronto, ON
Chairman and Executive Director, Brain and Cognition, Depression and Bipolar Support Alliance (DBSA)
Chicago, IL
Clinical Professor, Department of Psychiatry and Neurosciences
University of California School of Medicine
Riverside, CA

Statement of Need

Weight gain is an important contributing factor to metabolic syndrome, as it is a key component in the development of diabetes mellitus and cardiovascular disease - two diseases that carry significant medical morbidity and mortality.(1) In patients with psychiatric disorders, mortality linked to metabolic syndrome is compounded by behaviors such as heavy smoking, sedentary lifestyle, and poor eating habits. Weight gain can affect medication adherence(2) and data continue to emerge on the link between diabetes and cognitive(3) dysfunction, all of which can negatively impact patient outcomes. Treatment with antipsychotic agents may also play a role in weight gain, although available evidence suggests that its incidence and magnitude is quite variable among second-generation antipsychotics. This problem highlights several important needs: careful screening to recognize factors that may contribute to metabolic syndrome, appropriate selection of an antipsychotic agent, systematic monitoring, and effective management. In this neuroscienceCME TV activity, the experts will examine the impact of antipsychotic-induced weight gain and diabetes mellitus in the patient with severe mental illness, with a practical emphasis on evidence-based treatment strategies.


  1. Colton CW, Manderscheid RW. Congruencies in increased mortality rates, years of potential life lost, and causes of death among public mental health clients in eight states. Prev Chronic Dis 2006;3:A42. Epub 2006 Mar 15.
  2. Weiden PJ, Mackell JA, McDonnell DD. Obesity as a risk factor for antipsychotic noncompliance. Schizophr Res 2004;66:51–57.
  3. Khazaal Y, Frésard E, Zimmermann G, et al. Eating and weight related cognitions in people with schizophrenia: a case control study. Clin Pract Epidemol Ment Health 2006;312:29.

Activity Goal

To examine the impact of antipsychotic-induced weight gain and diabetes mellitus on cognition, cardiovascular disease, and adherence in patients with schizophrenia and bipolar disorder.

Learning Objectives

At the end of this CE activity, participants should be able to:

  • Examine the relationship between the pathophysiology of metabolic disorders and neuropsychiatric disorders.
  • Measure the impact of weight gain and diabetes mellitus on cognition, cardiovascular disease, and medication adherence.
  • Compare and contrast the pharmacologic properties of treatment options in an evidence-based model to identify the most appropriate therapy for each patient.

Financial Support

CME Outfitters, LLC, gratefully acknowledges an educational grant from Wyeth Pharmaceuticals and Solvay Pharmaceuticals in support of this CE activity.

Target Audience

Physicians, physician assistants, nurse practitioners, nurses, psychologists, social workers, certified case managers, pharmacists, and other healthcare professionals interested in mental health.

Credit Information

CME Credit (Physicians):
CME Outfitters, LLC, is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. CME Outfitters, LLC, designates this educational activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

CNE Credit (Nurses):
CME Outfitters, LLC, is an approved provider of continuing nursing education by the New York State Nurses Association, an accredited approver by the American Nurses Credentialing Center’s Commission on Accreditation.

It has been assigned code 6WASUP-PRV-066. 1.0 contact hours will be awarded upon successful completion.
Note to Nurse Practitioners: The content of this CNE activity pertains to Pharmacology.

CEP Credit (Psychologists):
CME Outfitters is approved by the American Psychological Association to sponsor continuing education for psychologists. CME Outfitters maintains responsibility for this program and its content. (1.0 CE credits)

NASW Credit (Social Workers):
This program was approved by the National Association of Social Workers (provider #886407722) for 1 continuing education contact hour.

CCMC Credit (Certified Case Managers):
This program has been approved for 1 hour by the Commission for Case Manager Certification (CCMC).

CPE Credit (Pharmacists):
ACPE CME Outfitters, LLC, is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education. 1.0 contact hours (0.1 CEUs)
Universal Program Number: 376-999-07-007-L01 (live presentation) 376-999-07-007-H01 (recorded programs)

Credit request forms/activity evaluations can be completed online at www.neuroscienceCME.com (click on the Testing/Certification link under the Resources tab - requires free account activation), and participants can print their certificate or statement of credit immediately. Otherwise, participants should fully complete and return both the credit request form and activity evaluation located within the course guide for this activity. A certificate or statement of credit will be mailed within 4-6 weeks to all who successfully complete these requirements.

Disclosure Declaration

All faculty participating in CME Outfitters continuing education activities are required to disclose any conflict(s) of interest related to the content of their presentation(s) as defined by the ACCME's Standards for Commercial Support, and other accrediting and regulatory bodies. Full disclosure of faculty relationships will be made on this website and within the activity course materials prior to the premiere date of this activity.

Questions about this activity? Call us at 877.CME.PROS (877.263.7767).

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