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Moving the Needle in Bipolar I Depression: Novel Strategies to Improve Patient Outcomes

Premiere Date: Tuesday, June 18, 2019

This activity offers CE credit for:

  1. Physicians (CME)
  2. Nurses (CNE)
  3. Nurse Practitioners (AANP)
  4. Physician Assistants (AAPA)
  5. Other

All other clinicians will receive a Certificate of Attendance stating this activity was certified for AMA PRA Category 1 Credit™

Credit Expiration Date:
Thursday, December 31, 2020


Roger S. McIntyre, MD, FRCPCRoger S. McIntyre, MD, FRCPC (Moderator)
Professor of Psychiatry and Pharmacology
University of Toronto
Chairman and Executive Director, Brain and Cognition Discovery Foundation (BCDF)
Head, Mood Disorders Psychopharmacology Unit
University Health Network
Toronto, Canada
Director, Depression and Bipolar Support Alliance (DBSA)
Chicago, IL
Professor and Nanshan Scholar, Guangzhou Medical University
Guangzhou, China
Adjunct Professor College of Medicine, Korea University
Seoul, Republic of Korea

Christoph U. Correll, MDChristoph U. Correll, MD 
Professor of Psychiatry and Molecular Medicine
Donald and Barbara Zucker School of Medicine at Hofstra/Northwell
Hempstead, NY
Investigator, Center for Psychiatric Neuroscience
Feinstein Institute for Medical Research
Manhasset, NY
Medical Director, Recognition and Prevention (RAP) Program
The Zucker Hillside Hospital, Department of Psychiatry
Glen Oaks, NY

Statement of Need

Bipolar I depression is a serious, debilitating disorder, and the challenge of management is compounded by the limited treatment options that are available. Current D2-targeted strategies to manage bipolar depression are limited in their effectiveness, as these approaches do not specifically target the neurobiology of the disease.

Data is emerging that demonstrates that the novel treatment strategies that target D2 receptors have shown significant clinical benefit in reducing symptom burden and improving quality of life in patients with bipolar I depression.

This CME Outfitters Snack features a faculty-guided interactive 3-D model animation that examines how D2 receptors relate to the pathogenesis of the bipolar I depression, and subsequently, how D2-targeted therapies exert their beneficial effects in promoting symptomatic remission and functional recovery.

Learning Objectives

At the end of this CE activity, participants should be able to:

  • Evaluate the role of dopamine D3 receptor function in the pathogenesis of bipolar I depression.
  • Analyze the current standards of care for bipolar I depression and their limitations in achieving ideal outcomes.
  • Incorporate recent clinical trial data on novel therapies with unique MOAs to achieve optimal clinical outcomes in bipolar I depression.

Financial Support

Supported by an educational grant from Allergan.

Target Audience

Physicians, physician assistants, nurse practitioners, nurses, and pharmacists.

Credit Information

CME Credit (Physicians):
CME Outfitters, LLC, is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CME Outfitters, LLC, designates this enduring material for a maximum of 0.5 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

AANP Credit (Nurse Practitioners):
This activity is approved for 0.5 contact hour(s) of continuing education (which includes 0.5 hours of pharmacology) by the American Association of Nurse Practitioners. Activity ID 19043698. This activity was planned in accordance with AANP Accreditation Standards and Policies.

AAPA Credit (Physician Assistants):
This activity has been reviewed by the AAPA Review Panel and is compliant with AAPA CME Criteria. This activity is designated for 0.5 AAPA Category 1 CME credits. Approval is valid for one year from 05/31/19. PAs should only claim credit commensurate with the extent of their participation.

CNE Credit (Nurses):
Provider approved by the California Board of Registered Nursing, Provider Number CEP 15510, for 0.5 contact hours.

Note to Nurse Practitioners and Clinical Nurse Specialists: the content of this activity pertains to pharmacology. Earn up to 0.5 contact hours of pharmacotherapeutic contact hours.

Note to Nurse Practitioners: Nurse Practitioners can apply for AMA PRA Category 1 Credit™ through the American Academy of Nurse Practitioners (AANP). AANP will accept AMA PRA Category 1 Credit™ from organizations accredited by the Accreditation Council for Continuing Medical Education. Nurse practitioners can also apply for credit through their state boards.

Note to Physician Assistants: AAPA accepts certificates of participation for educational activities certified for AMA PRA Category 1 CreditTM from organizations accredited by the Accreditation Council for Continuing Medical Education.

Post-tests, credit request forms, and activity evaluations must be completed online (requires free account activation), and participants can print their certificate or statement of credit immediately (75% pass rate required). This website supports all browsers except Internet Explorer for Mac. For complete technical requirements and privacy policy, visit

Disclosure Declaration

It is the policy of CME Outfitters, LLC, to ensure independence, balance, objectivity, and scientific rigor and integrity in all of their CE activities. Faculty must disclose to the participants any relationships with commercial companies whose products or devices may be mentioned in faculty presentations, or with the commercial supporter of this CE activity. CME Outfitters, LLC, has evaluated, identified, and attempted to resolve any potential conflicts of interest through a rigorous content validation procedure, use of evidence-based data/research, and a multidisciplinary peer review process. The following information is for participant information only. It is not assumed that these relationships will have a negative impact on the presentations.

Dr. McIntyre reports that he receives grants from CIHR/GACD/Chinese National Natural Research Foundation; and Stanley Medical Research Institute. He receives research support from CIHR/GACD/Chinese National Research Foundation; and Stanley Medical Research Institute. He is on the speakers bureau for Allergan; Janssen Pharmaceutical, Inc.; Lundbeck Canada Inc.; Minerva Neurosciences; Neurocrine Biosciences, Inc.; Otsuka Canada Pharmaceutical Inc.; Pfizer Inc.; Purdue Pharma Canada; Shire Pharma Canada ULC; Sunovion Pharmaceuticals Canada Inc.; and Takeda Pharmaceutical Company Limited.

Dr. Correll reports that he receives grants and research support from Janssen Pharmaceutical, Inc.; and Takeda Pharmaceuticals U.S.A., Inc. He is a consultant for Alkermes; Allergan; Angelini Pharma Inc.; Boehringer-Ingelheim; Gedeon Richter; Gerson Lehrman Group, Inc.; Indivior; IntraCellular Therapies; Janssen Pharmaceuticals, Inc.; Johnson & Johnson; LB Pharmaceuticals; Lundbeck; MedAvante-ProPhase, Inc.; Neurocrine Biosciences, Inc.; Novel Pharmaceuticals, Inc.; Pfizer Inc.; Recordati; Rovi; Servier; Sumitomo Dainippon Pharma Co., Ltd.; Sunovian Pharmaceuticals Inc.; Supernus Pharmaceuticals, Inc.; Takeda Pharmaceuticals U.S.A., Inc.; Teva Pharmaceutical Industries Ltd. He is a stock shareholder (directly purchased) of Janssen Pharmaceutical, Inc.; and Otsuka America Pharmaceutical, Inc. He provides expert testimony for Bristol-Myers Squibb Company. He is a Data Safety Monitoring Board Member/Chair for Boehringer-Ingelheim; Lundbeck; Rovi; Supernus Pharmaceuticals, Inc.; and Teva Pharmaceutical Industries Ltd.

Tony Graham, MD (peer reviewer) has no disclosures to report.

Mae Ochoa, RPh (peer reviewer) has no disclosures to report.

Kashemi D. Rorie, PhD (planning committee) has no disclosures to report.

Evan Luberger (planning committee) has no disclosures to report.

Jan Perez (planning committee) has no disclosures to report.

Sharon Tordoff (planning committee) has no disclosures to report.

Disclosures were obtained from the CME Outfitters, LLC staff: No disclosures to report.

CME Outfitters, LLC and the faculty do not endorse the use of any product outside of the FDA labeled indications. Medical professionals should not utilize the procedures, products, or diagnosis techniques discussed during this activity without evaluation of their patient for contraindications or dangers of use.

Questions about this activity? Call us at 877.CME.PROS (877.263.7767).


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