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Navigating the Sleep-Wake Cycle: A Guided 3-D Animation of the Neurotransmitters and Pathways of Treatments Used in Clinical Practice

Premiere Date: Monday, December 9, 2019

This activity offers CE credit for:

  1. Physicians (CME)
  2. Pharmacists (ACPE)
  3. ABIM (MOC)
  4. Other

All other clinicians will receive a Certificate of Attendance stating this activity was certified for AMA PRA Category 1 Credit™

Credit Expiration Date:
Thursday, December 31, 2020
Note: Credit Is No Longer Available


Thomas E. Scammell, MDThomas E. Scammell, MD 
Professor of Neurology
Harvard Medical School
Beth Israel Deaconess Medical Center
Boston Children's Hospital
Boston, MA

Statement of Need

Although sleep is an essential component of health and wellness, many people experience disruptions in their sleep-wake cycle that are severe enough to impair physiological and psychosocial functioning. Sleep disorders such as narcolepsy and hypersomnia represent a significant health problem with short- and long-term consequences, including having a negative impact on work performance and attendance, create a significant economic burden, and cause increased injuries and accidents, health care utilization, and more frequent and longer hospitalizations.

Recognizing the neurotransmitters involved in the sleep-wake cycle and how the suprachiasmatic nucleus (SCN) controls or regulates sleep is important, as is the identification and implementation of safe, effective therapies.

This interactive, faculty-guided 3-D animation will visually illustrate how the mechanisms of action (MOAs) of current and emerging therapies targets these neurotransmitters and shows how these therapies may impact the complex brain systems involved in the sleep-wake cycle.

Learning Objectives

At the end of this CE activity, participants should be able to:

  • Identify key neurotransmitters involved in the sleep-wake cycle.
  • Recognize how the suprachiasmatic nucleus (SCN) controls or regulates sleep.
  • Illustrate how the MOA of current and emerging agents may impact the sleep-wake cycle.

Financial Support

Supported by an educational grant from Jazz Pharmaceuticals, Inc.

Target Audience

Sleep specialists, internists, pulmonologists, nurse practitioners, physician assistants, nurses, and pharmacists.

Credit Information

CME Credit (Physicians):
CME Outfitters, LLC, is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CME Outfitters, LLC, designates this enduring material for a maximum of 0.5 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

CPE Credit (Pharmacists):
ACPE CME Outfitters, LLC, is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education. 0.5 contact hours (0.05 CEUs) Universal Activity Number:
Enduring: 0376-0000-19-060-H01-P

Type: Knowledge-based

ABIM/MOC Credit:
Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 0.5 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

Learning Formats
Enduring material

By providing your ABIM number, you consent to have CME Outfitters submit your participation in this activity to the ABIM through the ACCME PARS system.

MIPS Improvement Activity: This activity counts towards MIPS Improvement Activity requirements under the Medicare Access and CHIP Reauthorization Act of 2015 (MACRA). Clinicians should submit their improvement activities by attestation via the CMS Quality Payment Program website.

Note to Nurse Practitioners: Nurse Practitioners can apply for AMA PRA Category 1 Credit™ through the American Academy of Nurse Practitioners (AANP). AANP will accept AMA PRA Category 1 Credit™ from organizations accredited by the Accreditation Council for Continuing Medical Education. Nurse practitioners can also apply for credit through their state boards.

Note to Physician Assistants: AAPA accepts certificates of participation for educational activities certified for AMA PRA Category 1 CreditTM from organizations accredited by the Accreditation Council for Continuing Medical Education.

Post-tests, credit request forms, and activity evaluations must be completed online (requires free account activation), and participants can print their certificate or statement of credit immediately (75% pass rate required). This website supports all browsers except Internet Explorer for Mac. For complete technical requirements and privacy policy, visit

Disclosure Declaration

It is the policy of CME Outfitters, LLC, to ensure independence, balance, objectivity, and scientific rigor and integrity in all of their CE activities. Faculty must disclose to the participants any relationships with commercial companies whose products or devices may be mentioned in faculty presentations, or with the commercial supporter of this CE activity. CME Outfitters, LLC, has evaluated, identified, and attempted to resolve any potential conflicts of interest through a rigorous content validation procedure, use of evidence-based data/research, and a multidisciplinary peer review process. The following information is for participant information only. It is not assumed that these relationships will have a negative impact on the presentations.

Dr. Scammell reports that he is a consultant for Accelerator; Alkermes; Avadel; Axsome Therapeutics, Inc.; Eisai Inc.; Harmony Biosciences, LLC; Idorsia Pharmaceuticals Ltd; Jazz Pharmaceuticals, Inc.; Merck & Co., Inc.; Suven Life Sciences; and Takeda Pharmaceuticals U.S.A., Inc.

Marlon Graham, MD (peer reviewer) has no disclosures to report.

Mae Ochoa, RPh (peer reviewer) has no disclosures to report.

Kashemi D. Rorie, PhD (planning committee) has no disclosures to report.

Evan Luberger (planning committee) has no disclosures to report.

Jan Perez (planning committee) has no disclosures to report.

Sharon Tordoff (planning committee) has no disclosures to report.

Disclosures were obtained from the CME Outfitters, LLC staff: No disclosures to report.

Faculty of this CE activity may include discussions of products or devices that are not currently labeled for use by the FDA. The faculty have been informed of their responsibility to disclose to the audience if they will be discussing off-label or investigational uses (any uses not approved by the FDA) of products or devices.

Questions about this activity? Call us at 877.CME.PROS (877.263.7767).


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