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Meeting the Challenge: Improving Diagnosis of ALS

Premiere Date: Tuesday, February 1, 2022

This activity offers CE credit for:

  1. ABIM (MOC)
  2. Medicine (accme)
  3. Nursing (ANCC)
  4. Pharmacy (acpe)
  5. PA (aapa)
  6. Other

All other clinicians will receive a Certificate of Attendance stating this activity was certified for AMA PRA Category 1 Credit™

Credit Expiration Date:
Wednesday, February 1, 2023
Note: Credit Is No Longer Available


Jinsy A. Andrews, MD, MSc, FAANJinsy A. Andrews, MD, MSc, FAAN (Moderator)
Director of Neuromuscular Clinical Trials, Department of Neurology
Columbia University Irving Medical Center
New York, NY

John C. Novak, MS, MDJohn C. Novak, MS, MD 
OhioHealth Neurological Physicians
Director, OhioHealth ALS Clinic
Westerville, OH

Statement of Need

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative motor neuron disease that leads to paralysis of muscles required to move, speak, and breathe. It is the most common adult motor neuron disease that affects all races and ethnic backgrounds and is usually fatal within 3-5 years. Patients often go through multiple physicians and alternative diagnoses before presenting to ALS clinics with significant disability, and this delay in diagnosis precipitates suboptimal care, reduced treatment benefit, and exclusion from clinical trials. It is imperative that these diagnostic delays are reduced by recognizing early signs and symptoms, accelerating referrals to specialists, and simplifying diagnostic criteria.

This is the first installment in a CMEOutfitters series on the role of genetic testing and emerging therapies in ALS and focuses on recognizing the challenges in diagnosing ALS.

Learning Objectives

At the end of this CE activity, participants should be able to:

  • Recognize the challenges in diagnosis ALS.

Financial Support

Supported by an educational grant from Biogen MA, Inc.

Target Audience

Adult neurologists, geneticists, genetic counselors; primary care physicians, PAs, nurse practitioners, nurses, physical therapists, occupational therapists, otolaryngologists

Credit Information

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1 medical knowledge MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

Royal College MOC:
Through an agreement between the Accreditation Council for Continuing Medical Education and the Royal College of Physicians and Surgeons of Canada, medical practitioners participating in the Royal College MOC Program may record completion of accredited activities registered under the ACCME’s “CME in Support of MOC” program in Section 3 of the Royal College’s MOC Program.

MIPS Improvement Activity:
This activity counts towards MIPS Improvement Activity requirements under the Medicare Access and CHIP Reauthorization Act of 2015 (MACRA). Clinicians should submit their improvement activities by attestation via the CMS Quality Payment Program website.

Disclosure Declaration

It is the policy of CME Outfitters, LLC, to ensure independence, balance, objectivity, and scientific rigor and integrity in all of their CE activities. Faculty must disclose to the participants any relationships with commercial companies whose products or devices may be mentioned in faculty presentations, or with the commercial supporter of this CE activity. CME Outfitters, LLC, has evaluated, identified, and attempted to resolve any potential conflicts of interest through a rigorous content validation procedure, use of evidence-based data/research, and a multidisciplinary peer review process. The following information is for participant information only. It is not assumed that these relationships will have a negative impact on the presentations.

Dr. Andrews reports the following financial relationships:

Consultant: AL-S Pharma AG; Amylyx Pharmaceuticals Inc.; Biogen Idec; Cytokinetics; Denali Therapeutics; Neurosense Therapeutics; Orphazyme; and Wave Life Sciences

Research Support: Alexion Pharmaceuticals, Inc.;AZTherapies Inc.; Biogen Idec; Biohaven Pharmaceuticals; Clene Nanomedicine, Inc.; Cytokinetics; Healey Center at Massachusetts General Hospital; National Institutes of Health; Novartis AG; Orion; and Ra Pharmaceuticals, Inc.

Dr. Novak reports the following financial relationships:

Consultant: Amylyx Pharmaceuticals, Inc. and BridgeBio Pharma, Inc.

Grants: ALS Association

Speakers Bureau: Argenx and Amylyx Pharmaceuticals, Inc.

The following Peer Reviewer and CME Outfitters Staff have no financial relationships to disclose:

  • Jeffrey Helfand, DO (peer reviewer)
  • Kellie Busby, PharmD (planning committee)
  • Evan Luberger (planning committee)
  • Susan H Yarbrough, CHCP (planning committee)
  • Sharon Tordoff (planning committee)

  • Faculty of this CE activity may include discussions of products or devices that are not currently labeled for use by the FDA. The faculty have been informed of their responsibility to disclose to the audience if they will be discussing off-label or investigational uses (any uses not approved by the FDA) of products or devices.

    Questions about this activity? Call us at 877.CME.PROS (877.263.7767).


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