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Improving Medication Adherence and Outcomes in Transplant Recipients: The Impact of Medication Nonadherence

Premiere Date: Friday, June 28, 2013

This activity offers CE credit for:

  1. Physicians (CME)
  2. Pharmacists (ACPE)
  3. Other

All other clinicians will receive a Certificate of Attendance stating this activity was certified for AMA PRA Category 1 Credit™

Credit Expiration Date:
Saturday, June 28, 2014
Note: Credit Is No Longer Available


Flavio Vincenti, MDFlavio Vincenti, MD 
Professor of Clinical Medicine and Surgery
Medical Director, Kidney-Pancreas Program
University of California San Francisco
San Francisco, CA

Ron Shapiro, MDRon Shapiro, MD 
Professor of Surgery
The Robert J. Corry Chair in Transplantation Surgery
Associate Clinical Director
Thomas E. Starzl Transplantation Institute, University of Pittsburgh
Pittsburgh, PA

Statement of Need

Patients’ adherence to prescribed medication regimens is a challenge in many patients who have a chronic illness and the need for ongoing treatment. Fewer than half of individuals who are chronically ill actually adhere to prescribed medication regimens. Continuity of recommended post-surgical care is especially important in transplantation.(1) Lack of adherence to immunosuppressive medication increases the transplant recipients’ likelihood of graft rejection or failure. Non-adherence can also cause increased health complications, health care costs, and deaths.(2)

Adherence to immunosuppressive medication after transplantation is important to maximize good clinical benefits and outcomes; however, adherence remains suboptimal and not well-understood. Clinicians need to proactively partner with patients to educate each other and work together toward patient health and the success of a transplant.

This two-part webcast series will elucidate the barriers and causes of non-adherence to immunosuppressive medication and will offer clinicians timely and appropriate interventions.

Module 1: Impact of Medication Adherence Click here to begin this activity now
Module 2: Strategies to Improve Medication Adherence Click here to access this activity

Each module is certified for .75 AMA PRA Category 1 Credit™. We encourage participants to complete both modules to optimize the learning experience and to gain valuable insights for improving medication adherence in transplant recipients.

  1. De Geest S, Sabate E. Adherence to long-term therapies: evidence for action. Eur J Cardiovasc Nurs. 2003;2(4):323. PMID: 14667488.
  2. Pinsky BW, Takemoto SK, Lentine KL, et al. Transplant outcomes and economic costs associated with patient noncompliance to immunosuppression. Am J Transplant. 2009;9(11):2597-2606. PMID:19843035.

Activity Goal

The overarching goal of this activity is to delineate the major issues related to immunosuppressive medication (ISM) adherence and to improve routine clinical management that includes a patient-physician communication dynamic regarding quality of life issues, ongoing assessment, and treatment.

Learning Objectives

At the end of this CE activity, participants should be able to:

  • Describe the factors that impact medication adherence and the consequences from medication nonadherence in patients who have undergone kidney and/or liver transplantation.

Financial Support

Supported by an educational grant from Astellas Scientific and Medical Affairs, Inc.

Target Audience

Physicians, physician assistants, nurses, nurse practitioners, and pharmacists who are interested in or care for liver and kidney transplant patients.

Credit Information

CME Credit (Physicians):
CME Outfitters, LLC is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

CME Outfitters designates this enduring material for a maximum of .75 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

CPE Credit (Pharmacists):
ACPE CPE Credit (Pharmacists): CME Outfitters, LLC, is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education. .75 contact hours (0.075 CEUs)
Universal Activity Number: 0376-0000-13-013-H01-P
Activity Type: knowledge-based

Post-tests, credit request forms, and activity evaluations must be completed online at (requires free account activation), and participants can print their certificate or statement of credit immediately (80% pass rate required). This website supports all browsers except Internet Explorer for Mac. For complete technical requirements and privacy policy, visit

Disclosure of Relevant Financial Relationships with Commercial Interests

CME Outfitters, LLC adheres to the ACCME Standards, as well as those of the ACPE, and CBRN, regarding commercial support of continuing medical education. It is the policy of CME Outfitters, LLC, that the faculty and planning committee disclose real or apparent conflicts of interest relating to the topics of this educational activity, that relevant conflict(s) of interest are resolved, and also that speakers will disclose any unlabeled/unapproved use of drug(s) or device(s) during their presentation.

A conflict of interest is created when individuals in a position to control the content of CME have a relevant financial relationship with a commercial interest which therefore may bias his/her opinion and teaching. This may include receiving a salary, royalty, intellectual property rights, consulting fee, honoraria, stocks or other financial benefits.

CME Outfitters will identify, review, and resolve all conflicts of interest that speakers, authors or planners disclose prior to an educational activity being delivered to learners. Disclosure of a relationship is not intended to suggest or condone bias in any presentation but is made to provide participants with information that might be of potential importance to their evaluation of a presentation.

Relevant financial relationships exist between the following individuals and commercial interests:

Dr. Vincenti has disclosed that he has received research support from Astellas Scientific and Medical Affairs, Inc.; Bristol-Myers Squibb Company; and Novartis Corporation

Dr. Shapiro has nothing to disclose.

Rajeev R. Sinha, MD (peer reviewer) has nothing to disclose.

Ruth Cody, BSN, RN-BC (peer reviewer) has nothing to disclose.

Robert Kennedy, MA (planning committee) has nothing to disclose.

Joy Bartnett Leffler, MLA, NASW, CSE (planning committee) has nothing to disclose.

Sandra Haas Binford, MAEd (planning committee) has nothing to disclose.

Sharon Tordoff, CCMEP (planning committee) has nothing to disclose.

Faculty of this CE activity may include discussions of products or devices that are not currently labeled for use by the FDA. The faculty have been informed of their responsibility to disclose to the audience if they will be discussing off-label or investigational uses (any uses not approved by the FDA) of products or devices.

CME Outfitters, LLC, the faculty, and Astellas Scientific and Medical Affairs, Inc., do not endorse the use of any product outside of the FDA labeled indications. Medical professionals should not utilize the procedures, products, or diagnosis techniques discussed during this activity without evaluation of their patient for contraindications or dangers of use.

Questions about this activity? Call us at 877.CME.PROS (877.263.7767).


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